@article {289,
	title = {Preparation and preliminary biological screening of cholic acid-juvenoid conjugates},
	volume = {74},
	year = {Submitted},
	note = {08-10-200906-02-2012NormalInstitute of Experimental Botany, Academy of Sciences of the Czech Republic, Prague, Czech Republic. jurcek@ueb.cas.czenghttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=pubmed\&dopt=Abstract\&list_uids=19394354},
	pages = {779 - 785},
	abstract = {Steroidal compounds have been utilized as carriers and for modification of physico-chemical properties of model biologically active secondary alcohols - juvenoids. Juvenoids are juvenile hormone analogues - environmentally safe insecticides, possessing significant biological activity towards different arthropods groups in focus on insect pest species. Structure modification of juvenoids plays important role to control the rate of liberation and decomposition of juvenoid in digestive system and can also play important role in the mode of action towards selected insect. This study presents an approach to the synthesis of steroidal monomers and dimers carrying one and two molecules of a juvenoid in their structures. The prepared compounds were tested for their inhibition activity on reproduction of the blowfly Neobellieria (Sarcophaga) bullata. These steroid-juvenoid conjugates showed promising possibilities in synthesis of new unique biochemical insecticides. Preliminary biological test results of prepared compounds are presented.},
	keywords = {Animals, Cell Proliferation/drug effects, Cholic Acid/*chemistry, development, Dimerization, Diptera/cytology/drug effects/growth \&amp, Epithelial Cells/cytology/drug effects, Female, Juvenile Hormones/*chemical synthesis/chemistry/*pharmacology, Larva/drug effects/growth \&amp, Male, Pesticides/*chemical synthesis/chemistry/*pharmacology, Reproduction/drug effects},
	author = {Jurcek, O. and Wimmer, Z. and Svobodova, H. and Bennettova, B. and Kolehmainen, E. and Drasar, P.}
}
